Anti-Neutrophil Myeloperoxidase (Mpo-Anca): Autoimmune Disease Marker And Inflammatory Trigger
Anti-neutrophil myeloperoxidase (MPO) is an antibody that targets neutrophils, specifically the enzyme myeloperoxidase involved in phagocytosis. Its presence in the blood (as anti-neutrophil cytoplasmic antibody, ANCA) is associated with autoimmune diseases, particularly ANCA-associated vasculitis, including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). MPO-ANCA is a common marker in these…